AMRITA SHETTY

This is article about basic of chemistry in glance and brief were considered in the Question & answer format. This will be helpful to the student who want to ace in practical viva exams and written exams.  It is also helpful for preparation of interview. So, folks let commenced and learn just by glance on it: [Caution.: The aim of this article focus on the student and Job hunters to get right information at right time in unceratain and dilemma situation along with distraction of Social media and Binge. For others such as layman can also learn at their own risk. ] What is concentration of solution? The concentration of solution is defined as the amount of solute dissolved in a specific amount of solvent. What is Dilute solution? Solution containing relatively less amount of solute are called Dilute solution. What is Concentrated solution? Solution containing more amount of solute then the solution is called Concentrated solution What is Saturated solution? It contains less amoun...

This is article about basic of chemistry in glance and brief were considered in the Question & answer format. This will be helpful to the student who want to ace in practical viva exams and written exams.  It is also helpful for preparation of interview. So, folks let commenced and learn just by glance on it : [Caution.: The aim of this article focus on the student and Job hunters to get right information at right time in unceratain and dilemma situation along with distraction of Social media and Binge. For others such as layman can also learn at their own risk. ] What is Percentage of mass (W/W)? The mass of solute in gram dissolved in solvent to form 100 gram of solution is called Percentage of mass.  What is Percentage by volume (V/V)? It is defined as the ratio of the number of part by the solute to one hundred parts of the solution. What is Mole Fraction? Mole fraction of a component in a solution is defined as the ratio of number of moles of t...

  Infrared Spectroscopy: Introduction and classification of Infrared radiation (IR) By Amrita Shetty, 10 June 2021 Infrared spectroscopy is Spectroscopy study deal with the absorption of infrared radiation of electromagnetic spectrum by molecule. Mostly used by organic and inorganic chemist. IR spectrum gives sufficient information about the · Structure (identification of functional groups) of a compound. · Assess the purity of a compound. It is also known as vibrational-rotational spectroscopy is the absorption of infrared radiation by a molecule causes changes in their vibrational and rotational energy levels. IR spectrum is divided into 3 main categories: · · Far infrared (<400 cm −1 ) · Mid-infrared (4000–400 −1 ) · Near-infrared (13000–4000 cm −1 ) Mid IR spectrum is often used by chemist to identify organic molecule. Mid IR region are divided to two group.  Functional group region in which most of the functional groups present in organic molecules  exhibi...

  Analytical method validation as per   US-FDA (Part.:I) by Amrita Shetty, 03/04/2021        I.           I.  Reference standard & material.: Standard for use must be suitable. It should follow storage, usage condition, handling instruction for reference standard to avoid modification & contamination which lead to additional impurities and inaccurate analysis. This should be supported by qualification test report, certificate of analysis (COA) which include stability protocol, reports, and impurity profile information. This is often obtained from USP, European Pharmacopeia, Japanese pharmacopeia, World Health organisation or National institute of Standard and technology The standard for biological product is obtained from CBER. Reference material suitability is determined is not really captured by Drug product or product release test are ·          Exte...

Analytical method validation as per US-FDA by Amrita Shetty, 02/04/2021        I.             INTRODUCTION 1.       Analytical method required during product and process development activities are discussed in FDA guidance for industry on Process validation: 2.       Analytical procedure verification or validation data should be submitted in the corresponding section of the application in the ICH M2 eCTD: Electronic Common Technical Document Specification 3.       United States Pharmacopeias/National Formulator (USP/NF) or a validated procedure submitted that was determined to be acceptable by FDA. 4.       To apply an analytical method to a different drug product, appropriate validation or verification studies for compendial procedure with the matrix of the new product should be considered. 5...